Inter vs Sassuolo Prediction & Betting Tips (21 September)

Inter Milan host Sassuolo at the Giuseppe Meazza on September 21 in a clash that promises tension, redemption, and tactical intrigue. Cristian Chivu’s Inter side, still reeling from a dramatic 4-3 defeat to Juventus, will be desperate to steady their Serie A campaign after a rocky start. With just one win from their opening three matches, the Nerazzurri sit mid-table, their defensive frailties exposed despite a potent attack led by Marcus Thuram and Hakan Çalhanoğlu. Chivu has confirmed Yann Sommer will retain his spot in goal despite recent criticism, while Manuel Akanji is expected to start in defense following his deadline-day arrival from Manchester City.

Sassuolo, meanwhile, arrive in Milan buoyed by their first win of the season—a gritty 1-0 triumph over Lazio that marked Fabio Grosso’s maiden Serie A victory as Neroverdi boss. Alieu Fadera’s opportunistic goal sealed the points, and the Gambian forward is quickly becoming a key figure in Grosso’s evolving system. Domenico Berardi continues to lead by example, while midfielders Nemanja Matić and Aster Vranckx have added steel and structure. Despite their bottom-of-the-table position, Sassuolo’s recent performance suggests a team beginning to find its rhythm after two early defeats.



Historically, Sassuolo have been a thorn in Inter’s side, winning three of their last five meetings—including a 2-1 victory at San Siro in September 2023. However, Inter’s attacking form this season, with nine goals in three games, gives them a clear edge. Lautaro Martínez’s fitness remains a concern after international duty, but Chivu may still risk starting him alongside Thuram. The midfield trio of Barella, Çalhanoğlu, and Mkhitaryan offers creativity and control, while wingbacks Dumfries and Dimarco will look to stretch Sassuolo’s compact shape.

Expect a high-tempo encounter with chances at both ends. Sassuolo’s defensive discipline will be tested against Inter’s relentless pressure, but Grosso’s men have shown they can absorb and counter effectively. With both teams conceding regularly and Inter eager to bounce back, a 2-1 home win feels plausible—Thuram and Çalhanoğlu likely to find the net, while Berardi could snatch one for the visitors. It won’t be a walkover, but Inter’s firepower and home advantage should tilt the balance in their favor.

• Summary: Inter is going head to head with Sassuolo starting on 21 Sept 2025 at 18:45 UTC at San Siro/Giuseppe Meazza stadium, Milan city, Italy. The match is a part of the Serie A .
• Referee: Livio Marinelli