Lazio vs AS Roma Prediction & Betting Tips (21 September)

On the Lazio side, the defenders potentially holds Patric, Gigot and Lazzari and the Vecino, injured. On the other hand, the Romagnoli defensive taulier is back from suspension while the important winger Isaksen and the right side Marusic are again on feet. Scorers on the last day, attackers Zaccagni and Castellanos should start. Note that the Senegalese Dia marked after his entry into play. In the midfield, we find the Guendouzi and Rovella frameworks. Forbidden to recruitment, Lazio could only lift the option to buy players loaned, namely the defenders Nuno Tavares, Gigot and Pellegrini as well as the Rovella and Dele-Bashiru circles. In the opposite direction, it is necessary to point out the departure of the International French Hope Tchaouna (Burnley) and the Casal Defender (Bologna). Roma is still deprived of the winger who arrived at the club this summer Bailey, injured.

In addition, the excellent Brazilian side Wesley is announced uncertain. Scorer against Pisa, the Soulé Argentinian winger (1 goal in SA) may well establish himself as the main threat of the Louve club this season. He should be accompanied by his compatriot Dybala and the recruit Ferguson in the offensive trio. In sight with the Blues during the truce, the Manu Koné medium is well available. This summer, the Roma has lost the veteran Hummels (retreat), the right-back (Boca Juniors), the young marine goalkeeper (PSG) and the side Abdulhamid (Lens) and Salah-Eddine (PSV) while the excellent Piston Saelemaekers returned to Milan AC after its loan. On the other hand, we note the arrivals of defenders Ghilardi (Hellas Verona), Wesley (Flamengo), Ziolkowski (Legia Warsaw) and Tsimikas (Liverpool), the Middle El Aynaoui (Lens), the winger Bailey (Aston Villa) and the striker Ferguson (Brighton). 

Historically, the derby has been a balanced affair, but recent trends favor Roma. They’ve won two of the last five meetings, including a 2-0 triumph in January, while Lazio have managed just one win in that span. Yet, Lazio haven’t lost to Roma as the designated home side since 2016, a psychological edge they’ll be eager to preserve. Revenge will be a powerful motivator for Baroni’s squad, especially after back-to-back derby defeats. Expect a tactical chess match, with Lazio pressing high and Roma absorbing pressure before striking on the counter. The midfield battle—likely featuring Guendouzi and Cristante—could be decisive in dictating tempo and transitions.

As for the prediction, the stars seem aligned for a narrow Lazio victory. Despite Roma’s formidable form, Lazio’s recent attacking surge and home resilience suggest they’ll edge this one. A 2-1 scoreline feels plausible, with Castellanos and Zaccagni likely to find the net for the hosts, while Roma’s reply could come from the ever-dangerous Soulé. The derby rarely disappoints, and with both sides chasing top-four dreams, this clash promises drama, intensity, and a result that could tilt the balance of the season.