PSV vs Ajax Prediction & Betting Tips (21 September)

The Philips Stadion is set to host another chapter of Dutch football’s fiercest rivalry as PSV Eindhoven welcome Ajax Amsterdam in a high-stakes Eredivisie clash. Both sides have started the 2025–26 season with intent, sitting neck-and-neck near the top of the table. PSV, under the guidance of Peter Bosz, have bounced back from a rocky start to the year with a thrilling 5-3 win over NEC Nijmegen, showcasing attacking flair but also exposing defensive frailties. Ajax, led by returning coach John Heitinga, have been steady if unspectacular, grinding out results including a 3-1 victory over PEC Zwolle. With only one point separating the two, this fixture could tilt the balance in the title race.

PSV’s recent form has been buoyed by the resurgence of Ricardo Pepi, who netted twice against NEC, and the dynamic play of Ruben van Bommel and Ismael Saibari. Saibari, fresh off a successful international stint with Morocco, has added midfield bite and creativity. Captain Jerdy Schouten continues to anchor the side with composure, while Luuk de Jong remains a reliable goal threat. However, defensive inconsistencies persist, with Obispo’s inclusion over Flamingo and Gasiorowski raising eyebrows. Bosz’s tactical tweaks have improved fluidity, but the backline’s communication remains a concern, especially against Ajax’s pacey forwards.

Ajax, meanwhile, are navigating a transitional phase with Heitinga reinstated at the helm after stints abroad. The squad has seen fresh injections of talent, including Oscar Gloukh and Raul Moro, while veterans like Davy Klaassen and Kenneth Taylor provide midfield stability. Wout Weghorst has started the season brightly, scoring three goals in five appearances, and is expected to lead the line. Defensive solidity has been tested, particularly in away fixtures, but Ko Itakura and Lucas Rosa have added steel to the back four. With a Champions League tie against Inter looming, Ajax will be keen to assert domestic dominance before European distractions take hold.

Historically, this fixture has delivered drama, and the reverse encounter earlier this year saw Ajax edge PSV 2-0. Yet PSV’s unbeaten home record and attacking momentum suggest a different outcome this time. Expect a tightly contested match with PSV exploiting Ajax’s defensive gaps, particularly through wide play and set pieces. A 2-1 scoreline in favor of the hosts feels plausible, with De Jong and Saibari likely to find the net, while Weghorst may grab a consolation. In a season where every point counts, this clash could be the spark that reignites PSV’s title ambitions and tests Ajax’s resilience under pressure.