Napoli vs Pisa Prediction & Betting Tips (22 September)

Napoli welcome Pisa to the Stadio Diego Armando Maradona on September 22 in a clash that pits the reigning Serie A champions against a newly promoted side still searching for its first win. Antonio Conte’s Napoli have started the 2025–26 campaign in imperious fashion, winning all three of their opening matches and conceding just once. The midfield trio of Lobotka, McTominay, and De Bruyne has been instrumental, with the Belgian playmaker already netting twice since his high-profile move from Manchester City. Rasmus Højlund, another Premier League export, opened his account last weekend against Fiorentina, adding further firepower to a side that looks well-balanced and ruthless.

Pisa, on the other hand, have endured a rocky return to the top flight. Under Alberto Gilardino, the Tuscan outfit has managed just one point from three games, with their most recent outing ending in a 0–1 home defeat to Udinese. The team has struggled to convert chances, scoring only once so far this season. Injuries to key players like Tomas Esteves and Isak Vural have limited Gilardino’s options, while new arrivals such as Calvin Stengs and Raul Albiol are still finding their rhythm. Despite the setbacks, Pisa have shown flashes of resilience, particularly in their opening draw against Atalanta, and will be hoping to frustrate Napoli with a compact setup and counter-attacking intent.

Conte’s tactical discipline has been evident in Napoli’s defensive structure, with Buongiorno and Beukema forming a solid partnership at the back. Spinazzola’s overlapping runs and Politano’s creativity on the right flank have added width and unpredictability. With Alex Meret still recovering from a muscle issue, Vanja Milinković-Savić is expected to retain his spot between the posts. Napoli’s ability to dominate possession and press high has suffocated opponents, and against a Pisa side that has yet to score more than once in a match, the hosts are likely to dictate the tempo from the outset.

While Napoli are clear favorites, Pisa’s hunger to prove themselves could make this a tighter affair than expected. Gilardino may opt for a more aggressive approach, possibly starting M'Bala Nzola up front to exploit any gaps left by Napoli’s attacking full-backs. However, given the disparity in form and squad depth, a 2–1 win for Napoli seems the most plausible outcome. Expect the home side to take an early lead, with Pisa clawing one back in the second half before De Bruyne or Højlund seals the result late on.