Santos vs Sao Paulo Prediction & Betting Tips (22 September)

On behalf of the 24th day of Serie in Betano, Santos made an appointment with São Paulo this Monday at 1:30 am at the Estadio Urbano Caldeira. The locals are in great danger in this second part of the season. They are only in the 16th place in the Brazilian championship, with only one small length ahead of the red zone. The team trained by Juan Vojvoda failed to prevail during its previous 4 days. She has only known only 3 small victories in 10 receptions since the start of the Serie in Betano. A complicated situation when preparing this new poster.

São Paulo has many other ambitions in Serie in Betano. He is in the 7th position in the ranking and has lost only once in his last 10 days. However, he has just taken a hit on the head in the quarter-final first leg of Copa Libertadores, losing on the lawn of the LDU Quito 2-0. The men of Hernan Crespo therefore hope to relaunch themselves on the national scene, a few days from the quarter-final return of the South American competition. To fill up on confidence, they will do everything so as not to bow at the end of this trip.

In terms of personnel, Santos will be banking on their attacking duo to deliver, especially given their average of one goal per match at home. Defensive lapses have been their Achilles heel, and Vojvoda may opt for a more compact setup to counter São Paulo’s fluid transitions. São Paulo, meanwhile, will likely lean on their creative midfielders to unlock Santos’ backline. Crespo’s side has shown a knack for late goals, and their ability to maintain composure under pressure could be pivotal in a tightly contested affair.

While São Paulo may appear the favorites on paper, the home advantage and Santos’ urgency could produce a surprise. Expect a spirited performance from the hosts, who will look to avenge their previous defeat and reclaim local pride. With both teams capable of finding the net but also prone to defensive lapses, a 2-1 scoreline in favor of Santos feels plausible. It’s a prediction that defies the odds but aligns with the emotional intensity and unpredictability that this fixture so often delivers.

• Summary: Santos is going head to head with São Paulo starting on 21 Sept 2025 at 23:30 UTC at Estádio Urbano Caldeira stadium, Santos city, Brazil. The match is a part of the Brasileirão Betano .
• Santos Feedinco Rating: 6.92
• Sao Paulo Feedinco Rating: 6.86