St. Pauli vs Bayer Leverkusen Prediction & Betting Tips (27 September)

St. Pauli welcome Bayer Leverkusen to the Millerntor-Stadion on September 27th in a Bundesliga clash that promises intensity and attacking flair. The hosts have started the season brightly, sitting fifth in the table with seven points from four matches. Fabian Hürzeler’s side has shown resilience and creativity, especially in their recent 2-1 win over Augsburg and a gritty 3-3 draw against Dortmund . However, they’ll be without defender D. Nemeth and forward R. Jade-Jones due to injuries, which could test their depth against a Leverkusen side known for its offensive firepower.

Leverkusen, under Xabi Alonso’s guidance, have had a mixed start to the campaign, currently placed 11th with five points. Their recent 2-2 draw away at København in European competition and a 3-1 win over Eintracht Frankfurt highlight their attacking prowess, but defensive lapses remain a concern. Injuries to key forwards M. Terrier and A. Sarco, along with defender J. Quansah’s illness, have slightly blunted their edge. Still, with Florian Wirtz pulling strings in midfield and Victor Boniface leading the line, Leverkusen remain a threat in transition and set pieces.



Historically, Leverkusen have had the upper hand in this fixture, winning four of the last six Bundesliga meetings . Yet, St. Pauli’s recent form at home—unbeaten in their last three league matches—suggests they won’t be overawed. The Millerntor crowd has been a fortress, and with the team averaging 1.9 goals per home game, they’ll look to exploit Leverkusen’s tendency to concede late. Expect Hürzeler to deploy a high press and target Leverkusen’s fullbacks, who have struggled under pressure in recent outings.

In what’s shaping up to be a high-octane encounter, a 2-1 scoreline in favor of Bayer Leverkusen feels plausible. Both teams are likely to find the net, but Leverkusen’s superior finishing and experience in tight matches could tip the balance. St. Pauli will push hard, especially in the first half, but Leverkusen’s depth and tactical flexibility should see them edge it late. With both sides missing key players, expect an unpredictable rhythm—but one that ultimately favors the visitors.

• Summary: FC St. Pauli is going head to head with Bayer 04 Leverkusen starting on 27 Sept 2025 at 13:30 UTC at Millerntor-Stadion stadium, Hamburg - St. Pauli city, Germany. The match is a part of the Bundesliga .
• Referee: Martin Petersen