Lecce vs Napoli Prediction & Betting Tips (28 October)

Lecce will host Napoli at the Stadio Ettore Giardiniero - Via del Mare on October 28, 2025, in a Serie A clash that pits two teams with contrasting fortunes. Lecce, currently languishing near the bottom of the table, have struggled to find consistency, scoring just 0.71 goals per game and conceding 1.43 on average. Their recent goalless draw against Sassuolo did little to inspire confidence, though a narrow win over Parma earlier in the month showed flashes of resilience. Injuries have plagued their squad, with defenders Jean and Pérez sidelined, and Marchwinski still doubtful due to a ligament issue. Coach Roberto D'Aversa faces a tactical conundrum, needing to shore up a leaky defense while coaxing more creativity from a midfield that has yet to find rhythm.

Napoli, on the other hand, enter the fixture with momentum and ambition. Sitting second in the Serie A standings, they boast a potent attack led by Kevin De Bruyne, who has netted three goals in six appearances. Their midfield, anchored by Anguissa and McTominay, has been instrumental in maintaining possession dominance, averaging a league-best 62.9%. Despite missing key players like Lobotka, Rrahmani, and Lukaku due to various injuries, coach Rudi Garcia has managed to keep the squad cohesive and effective. Napoli’s recent win over Empoli, courtesy of a Kvaratskhelia penalty, underscored their ability to grind out results even when not at their best. With a deep bench and tactical flexibility, they remain one of the most formidable sides in the league.

Historically, Napoli have had the upper hand in this matchup, winning four of their last five meetings against Lecce, including a 1-0 victory in October 2024 and a 4-0 rout in September 2023. Lecce’s inability to score in those encounters highlights a recurring issue: breaking down Napoli’s disciplined backline. However, Lecce’s home advantage and the unpredictable nature of Serie A could offer a glimmer of hope. Players like Coulibaly and Camarda have shown flashes of promise, and if they can capitalize on any defensive lapses, an upset isn’t entirely out of the question. Still, Napoli’s superior shot creation and midfield control suggest they’ll dictate the tempo from kickoff.

Considering current form, squad depth, and historical precedent, a 2-1 victory for Napoli seems the most plausible outcome. Lecce might find the net through a moment of individual brilliance or a set-piece opportunity, but Napoli’s attacking trio and midfield dominance should be enough to secure all three points. Expect De Bruyne to be involved in the scoring, with Politano or Højlund likely to contribute as well. Lecce will fight hard, especially on home turf, but Napoli’s class and composure should ultimately tip the balance in their favor.