Mainz vs Hoffenheim Prediction & Betting Tips (21 November)

On the Mainz side, the important French full-back Caci and the unused defender Dal will not be able to hold their place this Friday evening. Otherwise, the entire group should be present for this meeting. We should certainly find the Japanese Sano (1 goal and 2 assists in the Bundesliga) and captain Amiri (3 goals and 1 assist in the Bundesliga) to make up the midfield of this formation. Striker Sieb (2 goals in the Bundesliga) is also present as is summer recruit Hollerbach who is still looking to score his first club goal.

As before the break, the tricolor Gendrey, defender Behrens, summer recruit Machida and striker Hlozek (2nd top scorer last season) should once again throw in the towel for Hoffenheim who can otherwise count on most of their best players for this meeting. We are of course thinking of the summer recruit Asllani (5 goals, 1 assist), to the interesting Lemperle (4 goals) and on Croatian international Kramaric (2 goals, 3 assists in Bundesliga). Prömel midfielders (4 goals, 1 pass) and Burger (2 goals, 1 assist) can also be dangerous. The probable line-ups for Mainz - Hoffenheim:

The tactical battle between Mainz and Hoffenheim promises to be fascinating. Mainz will likely rely on their compact defensive structure and quick transitions, hoping to exploit Hoffenheim’s occasional vulnerability at the back. Burkardt and Karim Onisiwo are expected to spearhead Mainz’s attack, while Hoffenheim will look to Kramaric and Beier to provide creativity and finishing. Both teams have had mixed results in recent weeks, and the pressure is mounting to secure points as the season heads into its decisive phase. The narrative surrounding this match is not just about form but also about momentum, with Mainz eager to climb away from the lower half of the table and Hoffenheim aiming to solidify their push for European qualification. The atmosphere at the MEWA Arena should add intensity, as Mainz supporters are known for creating a vibrant backdrop.

Considering the recent performances and the balance of strengths and weaknesses, this fixture could tilt in Mainz’s favor. Hoffenheim’s attacking talent is undeniable, but their defensive frailties have been exposed repeatedly in recent matches. Mainz, buoyed by their home crowd and the return of key players, appear well-positioned to capitalize on those gaps. While Hoffenheim will likely find the net through Kramaric or Beier, Mainz’s sharper edge in transitions and set pieces could prove decisive. Therefore, the most realistic prediction points toward a Mainz victory with a 3:1 scoreline, a result that would underline their resurgence and highlight Hoffenheim’s ongoing struggle for consistency.

• Summary: 1. FSV Mainz 05 is going head to head with TSG Hoffenheim starting on 21 Nov 2025 at 19:30 UTC at MEWA Arena stadium, Mainz city, Germany. The match is a part of the Bundesliga .
• Mainz Feedinco Rating: 6.69
• Hoffenheim Feedinco Rating: 6.82