U. De Chile vs Antofagasta Prediction & Betting Tips (5 November)

Universidad de Chile host Deportes Antofagasta in the upcoming Copa Chile clash, with La U arriving in outstanding form after dismantling Everton 4:1 on October 26, 2026, a game in which Eduardo Vargas scored a hat-trick and Matías Guerrero provided four assists. Just two weeks earlier, the Azules also cruised past Ñublense by a stunning 6:0 margin, underlining why Gustavo Álvarez's side is considered the clear favourite for this tie despite a recent setback against the very same opponent, who beat them 2:0 in the earlier cup meeting in October.

The revenge angle adds real spice to this fixture: Antofagasta's disciplined 2-0 win in the first encounter of the month proved they can frustrate Universidad de Chile's high defensive line, but La U have responded emphatically since then, scoring ten goals across their last two league outings. For the 2026/2027 season, Universidad de Chile can rely on a deep squad built around Vargas and Agustín Arce up front, creator Matías Guerrero, and the supporting cast of Ignacio Vásquez, Matías Zaldívia, Nicolás Fernández, Felipe Hormazábal, Lucas Barrera, Octavio Rivero, Charles Aránguiz and goalkeeper Hernán Galíndez, while Antofagasta will look to Cristian Palacios and Lucas Soto for goals and leadership.

From a betting perspective, the European odds reflect Universidad de Chile's dominance: a home win is priced around 1.45, the draw sits near 4.20, and an Antofagasta away victory is available at roughly 6.50, with over 2.5 goals trading at approximately 1.70 given La U's explosive attacking form. Antofagasta's away record in cup competition remains a concern for punters backing the underdog, as they have struggled to keep clean sheets against top-flight opposition away from the Calvo y Bascuñán.

Taking everything into account — home advantage at the Estadio Nacional Julio Martínez Prádanos, La U's ten-goal surge in their last two matches, and Antofagasta's limited attacking output on the road — our prediction is a 3:1 home win for Universidad de Chile, with Vargas and Arce once again expected to lead the line and seal a comfortable passage in the Copa Ch